Results of a new study identify specific clinical characteristics linked to poor quality of life in patients with PAH.
Abilio Reis, MD, and fellow researchers in Portugal have found that patients with pulmonary arterial hypertension (PAH) and other forms of pre-capillary pulmonary hypertension (pcPH) report poor quality of life (QoL) which is highly associated with World Health Organization (WHO) functional class, 6 minute walking distance, and Borg dyspnea indices.
Click through the slides for highlights of their study and a few clinical take home points at the end.
Source: Reis A, Santos M, Vicente M, et al. Health-related quality of life in pulmonary hypertension and its clinical correlates: a cross-section study. Biomed Res Int. 2018 Mar 19;2018:3924517. doi: 10.1155/2018/3924517. eCollection 2018.
PAH and Quality of Life. PAH has a significant impact on patient functionality, QoL, and health related (HR) QoL
Data are limited on the relationship between PAH disease severity/clinical characteristics and HRQoL impairment.
Authors sought to characterize HRQoL in patients with PAH and to explore clinical correlates.
The Study. Cross-sectional, observational study looking at consecutive patients with PAH and other forms of precapillary PH; mean diseae duration was <50 mos. One general and one disease-specific quality of life questionnaire was completed by each participant.
The Results. Most patients were WHO functional class (FC) I or II (69.4%). Both CAMPHOR and NHP scores were indicative of moderate HRQoL impairment. The most common PH etiologies were chronic thromboembolic pulmonary hypertension (24.5%), congenital heart disease (22.4%), idiopathic/heritable (22.4%), connective tissue disease (14.3%), and others (16.3%). Others included PAH-associated portal hypertension (3 patients), HIV (1 patient), and group 5 PH (4 patients).
Take Home Points